Under surface of the head of a human embryo about twenty-nine days old. (Frontonasal process labeled at center left.)
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During the third week of embryonic development, two areas of thickened ectoderm, the olfactory areas, appear immediately under the fore-brain in the anterior wall of the stomodeum, one on either side of a region termed the frontonasal prominence (or process).
By the upgrowth of the surrounding parts these areas are converted into pits, the olfactory pits, which indent the frontonasal prominence and divide it into a medial and two lateral nasal processes.
There is some evidence that development involves Sonic hedgehog and Fibroblast growth factor 8.
This article incorporates text in the public domain from the 20th edition of Gray’s Anatomy (1918)
^ Abzhanov A, Cordero DR, Sen J, Tabin CJ, Helms JA (December 2007). “Cross-regulatory interactions between Fgf8 and Shh in the avian frontonasal prominence”. Congenit Anom (Kyoto). 47 (4): 136–48. doi:10.1111/j.1741-4520.2007.00162.x. PMID 17988255.
hednk-027—Embryo Images at University of North Carolina
Flash animation at indiana.edu
ent/30 at eMedicine
Development of the head and neck
Lateral lingual swelling
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